副教授 硕士生导师 广州市青年后备人才
招生：化学学硕、材料与化工专硕
广东省广州市番禺区大学城外环西路230号
Tel/Wechat：15850560755
E-mail：q.hu@gzhu.edu.cn, q.hu@njust.edu.cn
https://www.researchgate.net/profile/Qiong_Hu13
教育及工作经历
2020/11-至今，广州大学化学化工学院，广州大学分析科学技术研究中心&广州市传感材料与器件重点实验室&广东省光电传感材料与器件工程技术研究中心，副教授
2018/07-2020/10，广州大学化学化工学院，博士后研究员
2013/09-2018/06，南京理工大学环境与生物工程学院，生物化工，工学博士
2009/09-2013/07，南京理工大学环境与生物工程学院，生物工程，工学学士
荣誉与学术兼职
(1) 广州市科协2023年青年科技人才托举对象
(2) 广州大学2020年“年度学术新锐”
(3) 中文核心期刊《分析测试学报》青年编委
(4) Journal of Analysis and Testing青年编委(ESCI收录)
(5) MDPI旗下SCI期刊Chemosensors客座编辑
(6) 广东省精准医学应用学会分子影像分会委员
本科教学
(1)《超分子化学》，专业选修课
(2)《超分子材料》，专业选修课
(3)《化学基础概论》，通识类选修课
(4)《疾病与健康》，通识类选修课
(5)《无机及分析化学》，专业必修课
(6)《无机化学实验》，专业必修课
研究兴趣
(1) 电化学生物传感
(2) 药物分析与精准医疗
(3) 肿瘤标志物早期诊断
(4) 即时检验与体外诊断
(5) 基因与蛋白质芯片
(6) 新型信号放大策略
(7) 可控/“活性”自由基聚合
科研项目
(1) 国家自然科学基金青年科学基金项目(2020.01-2022.12)，25万，已结题，主持
(2) 广东省自然科学基金面上项目(2022.01-2024.12)，10万，在研，主持
(3) 广州市科协2023年青年科技人才托举项目(2023.01-2024.12)，10万，在研，主持
(4) 广州市基础与应用基础研究项目(2022.04-2024.03)，5.0万，已结题，主持
(5) 广州市市校(院)联合资助项目(2022.04-2024.03)，20万，已结题，主持
(6) 广州大学青年人才项目(B类)，15万，已结题，主持
(7) 广州市博士后科研项目资助经费，20万，已结题，主持
(8) 中国博士后科学基金第64批面上资助，5.0万，已结题，主持
(9) 国家自然科学基金面上项目，64万，已结题，主要参与人
(10) 国家自然科学基金面上项目，65万，已结题，主要参与人
(11) 国家自然科学基金青年科学基金项目，25万，已结题，主要参与人
(12) 国家自然科学基金委员会科学部主任基金，10万，已结题，主要参与人
指导大学生创新训练项目
(1) 2021年大学生创新训练项目，省级，0.6万，已结题
(2) 2022年大学生创新训练项目，国家级，1.0万，在研
(3) 2023年大学生创新训练项目，省级，0.6万，在研
代表性研究成果
(1) 胡琼*, 李诗琪, 骆怡琳, 曹晓静, 梁伊依, 冯文星, 牛利*. 糖化白蛋白检测方法的研究进展. 分析化学, 2024. DOI: 10.19756/j.issn.0253-3820.221408.
(2) Lv J, Wan J, Wu D, Ye Z, Tian Y, Hong M, Chen S, Liu Y, Wang M, Hu Q*, Han D, Niu L*. Electrochemical aptamer-based biosensing of glycan-conjugated targets. Biomed. Anal., 2024, 1, 36-45.
(3) 李诗琪, 骆怡琳, 万建文, 胡琼*, 韩冬雪*, 牛利. 基于核酸适体的电化学生物传感研究. 分析测试学报, 2024, 43, 328-337.
(4) Wan J, Liang Y, Hu Q*, Liang Z, Feng W, Tian Y, Li S, Ye Z, Hong M, Han D, Niu L*. Amplification-free ratiometric electrochemical aptasensor for point-of-care detection of therapeutic monoclonal antibodies. Anal. Chem., 2023, 95, 14094-14100.
(5) Hu Q, Wan J, Liang Z, Li S, Feng W, Liang Y, Luo Y, Cao X, Ma Y, Han D*, Niu L. Dually amplified electrochemical aptasensor for endotoxin detection via target-assisted electrochemically mediated ATRP. Anal. Chem., 2023, 95, 5463-5469.
(6) Su L, Wan J, Hu Q*, Qin D*, Han D, Niu L*. Target-synergized biologically mediated RAFT polymerization for electrochemical aptasensing of femtomolar thrombin. Anal. Chem., 2023, 95, 4570-4575.
(7) Hu Q*, Li S, Liang Y, Feng W, Luo Y, Cao X, Niu L*. Boronate affinity-assisted electrochemically controlled ATRP for ultrasensitive electrochemical aptasensing of carcinoembryonic antigen. J. Electrochem., 2023, 29, 2218001.
(8) Hu Q, Feng W, Liang Y, Liang Z, Cao X, Li S, Luo Y, Wan J, Ma Y, Han D*, Niu L. Boronate affinity-amplified electrochemical aptasensing of lipopolysaccharide. Anal. Chem., 2022, 94, 17733-17738.
(9) Hu Q*, Cao X, Li S, Liang Y, Luo Y, Feng W, Han D*, Niu L. Electrochemically controlled atom transfer radical polymerization for electrochemical aptasensing of tumor biomarkers. Anal. Chem., 2022, 94, 13516-13521.
(10) Hu Q*, Wan J, Luo Y, Li S, Cao X, Feng W, Liang Y, Wang W*, Niu L*. Electrochemical detection of femtomolar DNA via boronate affinity-mediated decoration of polysaccharides with electroactive tags. Anal. Chem., 2022, 94, 12860-12865.
(11) Hu Q*, Wan J, Wang H, Cao X, Li S, Liang Y, Luo Y, Wang W*, Niu L*. Boronate-affinity crosslinking-based ratiometric electrochemical detection of glycoconjugates. Anal. Chem., 2022, 94, 9481-9486.
(12) Hu Q*, Hu S, Li S, Liu S, Liang Y, Cao X, Luo Y, Xu W, Wang H, Wan J, Feng W, Niu L*. Boronate affinity-based electrochemical aptasensor for point-of-care glycoprotein detection. Anal. Chem., 2022, 94, 10206-10212.
(13) Hu Q*, Su L, Luo Y, Cao X, Hu S, Li S, Liang Y, Liu S, Xu W, Qin D, Niu L*. Biologically mediated RAFT polymerization for electrochemical sensing of kinase activity. Anal. Chem., 2022, 94, 6200-6205.
(14) 严铟蕾, 胡琼*, 牛利*. 超分子水凝胶的制备与应用. 材料研究与应用, 2022, 16, 785-793.
(15) Hu Q, Su L, Chen Z, Huang Y, Qin D, Niu L*. Coenzyme-mediated electro-RAFT polymerization for amplified electrochemical interrogation of trypsin activity. Anal. Chem., 2021, 93, 9602-9608.
(16) Hu Q*, Luo Y, Cao X, Chen Z, Huang Y, Niu L*. Bioinspired electro-RAFT polymerization for electrochemical sensing of nucleic acids. ACS Appl. Mater. Interfaces, 2021, 13, 54794-54800.
(17) Hu Q, Su L, Mao Y, Gan S, Bao Y, Qin D, Wang W*, Zhang Y, Niu L*. Electrochemically induced grafting of ferrocenyl polymers for ultrasensitive cleavage-based interrogation of matrix metalloproteinase activity. Biosens. Bioelectron., 2021, 178, 113010.
(18) Hu Q, Su L, Huang Y, Chen Z, Cao X, Luo Y, Qin D, Niu L*. Coenzyme-mediated electro-grafting for ultrasensitive electrochemical DNA biosensing. Sens. Actuators, B, 2021, 346, 130551.
(19) 胡琼, 甘世宇, 包宇, 韩冬雪, 牛利*. 基于可控/“活性”自由基聚合的生物传感分析. 化工进展, 2021, 40, 2710-2718.
(20) Hu Q, Bao Y, Gan S, Zhang Y*, Han D, Niu L*. Electrochemically controlled grafting of polymers for ultrasensitive electrochemical assay of trypsin activity. Biosens. Bioelectron., 2020, 165, 112358.
(21) Hu Q, Gan S, Bao Y, Zhang Y*, Han D, Niu L. Electrochemically controlled ATRP for cleavage-based electrochemical detection of the prostate-specific antigen at femtomolar level concentrations. Anal. Chem., 2020, 92, 15982-15988.
(22) Hu Q, Gan S, Bao Y, Zhang Y, Han D, Niu L*. Controlled/“living” radical polymerization-based signal amplification strategies for biosensing. J. Mater. Chem. B, 2020, 8, 3327-3340.
(23) Hu Q, Bao Y, Gan S, Zhang Y*, Han D, Niu L. Amplified electrochemical biosensing of thrombin activity by RAFT polymerization. Anal. Chem., 2020, 92, 3470-3476.
(24) Hu Q, Kong J*, Han D, Bao Y, Zhang X*, Zhang Y*, Niu L. Ultrasensitive peptide-based electrochemical detection of protein kinase activity amplified by RAFT polymerization. Talanta, 2020, 206, 120173.
(25) Hu Q, Kong J*, Han D, Niu L*, Zhang X*. Electrochemical DNA biosensing via electrochemically controlled reversible addition–fragmentation chain transfer polymerization. ACS Sens., 2019, 4, 235-241.
(26) Hu Q, Kong J*, Han D, Zhang Y*, Bao Y, Zhang X, Niu L*. Electrochemically controlled RAFT polymerization for highly sensitive electrochemical biosensing of protein kinase activity. Anal. Chem., 2019, 91, 1936-1943.
(27) Hu Q, Han D, Gan S*, Bao Y, Niu L*. Surface-initiated-reversible-addition–fragmentation-chain-transfer polymerization for electrochemical DNA biosensing. Anal. Chem., 2018, 90, 12207-12213.
(28) Hu Q, Wang Q, Jiang C, Zhang J, Kong J*, Zhang X*. Electrochemically mediated polymerization for highly sensitive detection of protein kinase activity. Biosens. Bioelectron., 2018, 110, 52-57.
(29) Hu Q, Wang Q, Kong J*, Li L, Zhang X*. Electrochemically mediated in situ growth of electroactive polymers for highly sensitive detection of double-stranded DNA without sequence-preference. Biosens. Bioelectron., 2018, 101, 1-6.
(30) Hu Q, Wang Q, Sun G, Kong J*, Zhang X*. Electrochemically mediated surface-initiated de novo growth of polymers for amplified electrochemical detection of DNA. Anal. Chem., 2017, 89, 9253-9259.
(31) Hu Q, Li L, Sun G, Li D, Kong J*, Huang W, Zhang X*. 5-Carboxyfluorescein: Intrinsic peroxidase-like catalytic activity and its application in the biomimetic synthesis of polyaniline nanoplatelets. J. Mater. Chem. B, 2017, 5, 5937-5941.
(32) Hu Q, Ma K, Mei Y, He M, Kong J*, Zhang X*. Metal-to-ligand charge-transfer: Applications to visual detection of β-galactosidase activity and sandwich immunoassay. Talanta, 2017, 167, 253-259.
(33) Hu Q, Zhou B, Dang P, Li L, Kong J*, Zhang X*. Facile colorimetric assay of alkaline phosphatase activity using Fe(II)-phenanthroline reporter. Anal. Chim. Acta, 2017, 950, 170-177.)
(34) Hu Q, He M, Mei Y, Feng W, Jing S, Kong J*, Zhang X*. Sensitive and selective colorimetric assay of alkaline phosphatase activity with Cu(II)-phenanthroline complex. Talanta, 2017, 163, 146-152.
(35) Hu Q, Zhou B, Li F, Kong J*, Zhang X*. Turn‐on colorimetric platform for dual activity detection of acid and alkaline phosphatase in human whole blood. Chem. Asian J., 2016, 11, 3040-3045.
(36) Hu Q, Kong J*, Li Y, Zhang X*. A signal-on electrochemical DNA biosensor based on potential-assisted Cu(I)-catalyzed azide-alkyne cycloaddition mediated labeling of hairpin-like oligonucleotide with electroactive probe. Talanta, 2016, 147, 516-522.
(37) Hu Q, Deng X, Yu X, Kong J*, Zhang X*. One-step conjugation of aminoferrocene to phosphate groups as electroactive probes for electrochemical detection of sequence-specific DNA. Biosens. Bioelectron., 2015, 65, 71-77.
(38) Hu Q, Hu W, Kong J*, Zhang X*. Ultrasensitive electrochemical DNA biosensor by exploiting hematin as efficient biomimetic catalyst toward in situ metallization. Biosens. Bioelectron., 2015, 63, 269-275.
(39) Hu Q, Deng X, Kong J*, Dong Y, Liu Q, Zhang X*. Simple and fast electrochemical detection of sequence-specific DNA via click chemistry-mediated labeling of hairpin DNA probes with ethynylferrocene. Analyst, 2015, 140, 4154-4161.
(40) Hu Q, Hu W, Kong J*, Zhang X*. PNA-based DNA assay with attomolar detection limit based on polygalacturonic acid mediated in-situ deposition of metallic silver on a gold electrode. Microchim. Acta, 2015, 182, 427-434.
(41) Qian Q, Hu Q, Li L, Shi P, Zhou J, Kong J*, Zhang X, Sun G*, Huang W*. Sensitive fiber microelectrode made of nickel hydroxide nanosheets embedded in highly-aligned carbon nanotube scaffold for nonenzymatic glucose determination. Sens. Actuators, B, 2018, 257, 23-28. (co-first author)
(42) Mei Y, Hu Q, Zhou B, Zhang Y, He M, Xu T, Li F, Kong J*. Fluorescence quenching based alkaline phosphatase activity detection. Talanta, 2018, 176, 52-58. (co-first author)
(43) Liu Q, Hu Q, Li L, Kong J*, Zhang X*. Click chemistry-based aptasensor for highly sensitive electrochemical detection of thrombin. Anal. Methods, 2017, 9, 3825-3830. (co-first author)
(44) He M, Hu Q, Mei Y, Zhou B, Kong J*, Zhang X. Metal-to-ligand charge-transfer-based visual detection of alkaline phosphatase activity. Anal. Sci., 2018, 34, 341-347. (co-first author)
(45) 牛利，胡琼，曹晓静，骆怡琳，李诗琪，梁伊依，冯文星. 一种糖轭合物的比率型电化学检测方法. (发明专利，专利号：ZL202210664735.9)
(46) 胡琼，万建文，牛利，韩冬雪. 一种检测糖化白蛋白的电化学适体传感器及传感方法. (发明专利，申请号：202310963374.2)
(47) 牛利，胡琼. 一种生物学介导的RAFT聚合方法. (发明专利，申请号：202210232483.2)
(48) 牛利，胡琼. 一种糖蛋白的电化学适体检测方法. (发明专利，申请号：202210361907.5)
(49) 孔金明，胡琼，何玟辉，梅亚琦，张学记. 一种碱性磷酸酶活性的测定方法. (发明专利，专利号：ZL201510666268.3)
(50) 孔金明，胡琼，梅亚琦，何玟辉，张学记. 一种酸性磷酸酶活性的测定方法. (发明专利，专利号：ZL201610013539.X)
其他情况
(1) 广州大学2023年校级教学成果奖(高等教育本科类)，一等奖，排名第七；
(2) Biosensors and Bioelectronics、Sensors and Actuators B、Analytica Chimica Acta、Talanta、Electroanalysis、Spectrochimica Acta Part A、Microchemical Journal、RSC Advances、Food Hydrocolloids for Health、Journal of Composites Science等国际期刊的资深评审专家。
